Kinesins and Cancer / (Record no. 67490)

MARC details
000 -LEADER
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001 - CONTROL NUMBER
control field 21682770
003 - CONTROL NUMBER IDENTIFIER
control field ugUCULIB
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20251103130807.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m |o d |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr |||||||||||
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150302s2015 ne |||| o |||| 0|eng
010 ## - LIBRARY OF CONGRESS CONTROL NUMBER
LC control number 2019749002
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9789401797320
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/978-94-017-9732-0
Source of number or code doi
035 ## - SYSTEM CONTROL NUMBER
System control number 21682770
035 ## - SYSTEM CONTROL NUMBER
System control number (DE-He213)978-94-017-9732-0
040 ## - CATALOGING SOURCE
Original cataloging agency DLC
Language of cataloging eng
Description conventions pn
Transcribing agency UCULIB
Modifying agency UCULIB
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED062000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCL
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCL
Source thema
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 614.5999
Edition number 23
Item number KIN
245 00 - TITLE STATEMENT
Title Kinesins and Cancer /
Statement of responsibility, etc edited by Frank Kozielski, FSB.
250 ## - EDITION STATEMENT
Edition statement 1st ed.
Remainder of edition statement 2015.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc London :
Name of publisher, distributor, etc ill. ;
Date of publication, distribution, etc c2015.
300 ## - PHYSICAL DESCRIPTION
Extent x, 271 p. :
Other physical details ill. (some col.) ;
Dimensions 24 cm.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface -- The kinesin superfamily -- The discovery and development of Eg5 inhibitors for the clinic -- Mechanism of action of Eg5 inhibitors -- Clinical trials of mitotic kinesin inhibitors -- Kif15; a useful target for anti-cancer therapy?.- Down-regulating CENP-E activity: for better or for worse -- The human kinesin-14 motor KifC1/HSET is an attractive anti-cancer drug target.-Kinesin-13 Microtubule Depolymerizing Proteins as targets for cancer therapy -- Chromokinesins in genome maintenance and cancer -- Kif14: a clinically relevant kinesin and potential target for cancer therapy -- Kinesin-8 members and their potential as biomarker or therapeutic target -- The kinesin-6 members MKLP1, MKLP2 and MPP -- Non-motor spindle proteins as cancer chemotherapy targets -- Inhibitors of mitotic kinesins for cancer treatment: consequences for neurons -- Index.
520 ## - SUMMARY, ETC.
Summary, etc This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cancer research.
9 (RLIN) 32075
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cell biology.
9 (RLIN) 32076
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicinal chemistry.
9 (RLIN) 32077
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Oncology.
9 (RLIN) 32078
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Proteins.
9 (RLIN) 32079
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cancer Research.
9 (RLIN) 32080
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cell Biology.
9 (RLIN) 32081
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medicinal Chemistry.
9 (RLIN) 32082
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Oncology.
9 (RLIN) 32078
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Protein-Ligand Interactions.
9 (RLIN) 32083
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kozielski, FSB, Frank.
Relator term editor.
9 (RLIN) 32084
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Kinesins and cancer
International Standard Book Number 9789401797313
Record control number (DLC) 2015932649
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789401797313
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789401797337
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Printed edition:
International Standard Book Number 9789402403657
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
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942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Books
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     UCU School of Medicine Library UCU School of Medicine Library Closed Access l Short Loan 03.11.2025   614.5999 KIN 161950 03.11.2025 03.11.2025 Books